Game Day: Bills vs. Cardinals Previews and Predictions!

It’s game day! The Buffalo Bills host the Arizona Cardinals at 1:00 p.m. EDT today in the season opener for both teams in what should be a raucous Highmark Stadium.

Today’s edition of Buffalo Rumblinks features game predictions, games to watch and game keys from the Bills’ reporters as Buffalo looks to win its home opener for the third straight season.

Game Preview: Bills vs. Cardinals

The Bills are seeking their fifth consecutive AFC East title. The Cardinals are looking to improve on last year’s disappointing 4-13 finish. At first glance, this matchup appears to feature teams on opposite sides of the NFL standings, but Arizona will not be an easy opponent for Buffalo.

We break down the key matchups, including how quarterback Kyler Murray has re-established himself as a dual-threat signal caller, how Buffalo will have a busy time containing talented tight end Trey McBride, how Josh Allen and the Bills offense could have a big day against the porous Cardinals defense, and much more!

Predictions: Bills vs. Cardinals

Bills reporters and NFL experts share their thoughts on how they think the Week 1 showdown in Orchard Park, New York, will play out.

Final Injury Report: Bills vs. Cardinals

Defensive end Dawuane Smoot (toe) is officially questionable, while rookie defensive end Javon Solomon (oblique) has been ruled out by Buffalo. For Arizona, wide receiver Xavier Weaver (oblique) is ruled out, while tight end Tip Reiman (ankle) and safety Joey Blount (back) are questionable.

How to Watch Bills vs. Cardinals from Home

For those Bills Mafia members who can’t make it to Highmark Stadium, don’t worry. We’ve got plenty of ways for you to watch and follow the action from home!

More Bills News

We’ll learn how offensive coordinator Joe Brady has empowered his players to take ownership of the offense, find out why defensive end Greg Rousseau is a man on a mission entering the 2024 season, discuss expectations for rookie wide receiver Keon Coleman, find out which Bills’ Hall of Famer is calling the shots, and more!